93. Functional Genomic Analysis with Dr. Bob Miller

Dr. Bob Miller 0:04

We're gonna look back someday Dr. Gray and say what are we thinking?

Dr. Stephanie Gray 0:12

Welcome to the your longevity blueprint podcast. I'm your host, Dr. Stephanie gray. My number one goal with the show is to help you discover your personalized plan to build your dream health and live a longer, happier, truly healthier life. You are about to hear from Dr. Bob Miller today is all about nutrigenomics we're going to talk about how nutrition and even environment influences our genes. This interview just keeps getting better and better. So stay till the end. Let's get rolling.

Welcome to another episode of The your longevity blueprint podcast. today. My guest is Dr. Bob Miller, who's a traditional naturopath specializing in the field of genetic specific nutrition. He earned his traditional naturopathic degree from Trinity School of Natural Health and is board certified through the a n Ma. In 1993. He opened the tree of life practice and has served as a traditional naturopath for 27 years. For the past several years, he has been engaged exclusively with functional nutritional genetic variants and related research specializing in nutritional support for those with chronic Lyme disease. We're going to talk a little bit about all that and what that means today. So welcome to the show, Dr. Miller.

Dr. Bob Miller 1:22

Well, it's my pleasure to be here. I'm looking forward to it. We've been planning this for a long time.

Dr. Stephanie Gray 1:28

Yes, I've known you for quite a while. So in chapter three of my book, speaking of your longevity blueprint, you actually helped me I sent that chapter to you. And you, you helped me make sure that that made sense than what I was saying was, was accurate and valid. And you've helped me along the way learn a lot of what we're going to talk about today. But referencing my book, I do want the audience to just especially if you haven't read the book, think about the electrical work through your house. So there's really no need to have all your lights turned on all at once. Right? When you wake up in the morning, you might turn on your bedroom lights, and maybe your bathroom lights, then maybe your kitchen lights as you prepare breakfast. But there's quite the intricate process that happens in that quick second right of you turning those lights on or turning them off with flicker of that switch. And similarly, our genes fuel every enzymatic reaction in every cell in our body.

So if you haven't quite figured out in my analogy, I'm comparing in chapter three of my book, the electrical work in the house to genetics and our body. And that's what we're going to talk about today, genetics. So a disrupted supply during power outages. And blackouts can stop operations and inconvenience those affected right power outages, never fun. And if you keep lights turned on too long, they can also kind of burn out right. And so similarly, that's what can happen with our genes. Ultimately, we just want to keep the good genes turned on the bad genes less active as turned off as we can, right we want those good genes working to their full potential.

And so today we're going to talk about how nutrition and environment influences those lights, which is right or those genes, right? Because again, we want to keep our good genes functioning very effectively. And we don't want to be as negatively impacted by the bad genes. I've heard you say some individuals haven't inherited that genetic lottery. And so if we are one of those individuals, you haven't inherited the genetic lottery, we want to make sure you can be as least negatively impacted as possible. So this might sound a little confusing, but I have an expert here today to hopefully make this a little easier because it's even hard for me to talk. So Bob, tell us how you got interested in nutrigenomics. And the story behind starting your company?

Dr. Bob Miller 3:19

Sure. Well, mainly the personal story behind my company was was in my late 20s, I came down with a serious case of ulcerative colitis. I was in the hospital for 21 days, almost half my blood than I hemorrhaged in wasn't sure if I'd see the morning. Yikes. And the solution was, well, let's cut out the column. And is like I didn't like that idea a whole lot. So I was in a completely different field. At that time, I was an executive in telecommunications and just became very interested in holistic healing. And of course, I'm 66 today at the time of this recording, Colin's doing just fine. But I have to work at it. Because I'm one of those people who didn't hit the lottery on the genetics. Sure. So what company so that's what got me down to my pathway to traditional nature, apathy. But then I'll remember one day I was looking at at homocysteine. And it's like, oh, the higher the homocysteine, the sooner you die from all causes. I mean, there's a book out there called the age factor that talks about how we need homocysteine to make our glutathione and other things.

But if it's too high, it stimulates all kinds of inflammatory cascades. Yes. So then I started, you know, rather naively looking at, you know, the methylation process, and there's enzymes behind that. It was love at first sight. And I haven't looked back since and this is so cool. I've been studying it ever, ever since then. Keep in mind, you know, I'm not a geneticist or traditional naturopath. So we don't look at genes related to disease, you know, because they're our genetics. Well, firstly, everyone's familiar with, like, 23andme ancestry that it looks at where you're from, and then you know, everyone's familiar with Oh, do you have this gene that would lead to breast cancer, or this gene that could lead to dementia and that's not What I look at, you know, we look at what's called functional genomics. And that's a completely new field that I believe where we're pioneering. And and just you gave that an ethical analogy. And let me just jump off on that one. You know, I often tell my clients, you know, we'd fats, carbohydrates, proteins, we drink water, breathe air and exposed to sunlight. And everything gets made from that.

I mean, it's just yeah, yeah, think about it. So what happens is that enzymes take one substance, they pull something else in, make something new, then another enzyme comes along, and take that put something else in the toilet. And that's how everything gets made. I mean, it's astonishing, our hair or skin, or nails, or red blood cells, our neurotransmitters all get made, because one enzymatic process after another is happening, and it's your DNA that makes those enzymes. So at the moment, were conceived, when the sperm and the egg goes together, your genetic profile is made. And I'm sure people have seen like a ladder, you know, the, the twists, and on the one side, we get the nucleotide from other the other side from Father. And there's only four of them. And what happens is that there's one that's ideal that makes that enzyme works the best. And then sometimes you'll get what's called a snip, or, you know, mutation all kinds of causes names for it, or just not the one that's most regular, because I don't like to say anyone's mutated that start defective, that's not a good term, it's just the snip, that's just not as effective.

So therefore, that enzyme may not be at 100%, good might be at 80%, it might be at 40%. So in simplicity, we call it heterozygous when one side is not optimal, homozygous when both sides are not optimal. So again, in the software that we developed, and the consoling we do, we're not looking at disease, we're looking at function. And, and what I mean by that, if you go back to the whale, traditional naturopathic philosophy, it's that inflammation is what causes all the problems, or the Mulu, or the terrain, it's the terrain that allows it to happen. So that's why you know, you can have a classroom of children, one can always get sick and the other one doesn't. By being immune system, it's also the terrain. So that's the traditional naturopathic philosophy of is the terrain optimal? Is nutrients coming in and being absorbed? Is waste being carried out?

Are we making not as much free radicals as we should? Are we making enough antioxidants? And that's what we do in functional genomics. We look at do you have some genetic issues that might make more inflammation, and we'll get into the specifics if you'd like. And then we also look at why we be making not enough antioxidants. Let me just explain that briefly. For the person, this is all new to them. I'm sure they've heard the nerve, the name of free radical, that's basically an atom that's got one of its electrons missing, because everything's made of atoms hit the neutron proton electron that spins. And that needs to be balanced to free radical is one of those electrons gets ripped off. And I oxidants have a spare electron.

And they donate and neutralize that. So we look at are there processes inside the body that might be making too many free radicals? And are might there be weakness that you're not making enough antioxidants? Might some of your detox pathways may not be as optimal? Might your digestion, your ability with fats or your mitochondria? Is making energy as active as it should? And if not, we can step in and support it. You know, one things I like to say, with functional genomics, we never have any bad news. We don't drop any bombs on anybody. Oh, it looks like you're going to get fill in the blank disease. One of my favorite jokes is the only bad news I could ever give you, it'd be like Sorry, I don't see anything I can help you with.

Other than that, everything we see, we can be supportive of. So in functional genomics, we're not treating the disease, we're looking where there might be less than optimal function. And then how do we support that? You know, how do we support that enzyme? So for example, if an enzyme job is to make something and it's not doing it, well, there's nutrients will actually support that enzyme. Or, for example, if you're not making enough something, well, then just give you some of that, okay, detox process help take that out, or help take the load off. One of the examples we often give is histamine, we see so many people who have high histamine, it's become a rampant problem. And you know, the traditional thought is we'll take antihistamines because they block the receptor site.

Well, that might give you some short term relief, but you're really not getting to the root of the problem. There's many ways that the body can produce excess histamine, or there's many pathways that the body clears system and then maybe less than optimal, or there may be not enough cofactors for the enzymes that clear histamine, or there might be other things that actually block that clearing of the histamine. So that's why we call this the 3d chess game played underwater. are multiple factors, not just simple answers? So they're a brief explanation of the 10,000 feet of Olmec. So, and then we can give them as much specific detail as you'd like. You're

Dr. Stephanie Gray 10:13

sure, yeah, I want to unpack a little bit of what you said that was all great. So you talked about functional genomics. But I also want to make sure for the audience that we define nutrigenomics. So correct me if I'm wrong, but then that, that also then blends in nutrition, looking at genetics, right? The the study of the interaction of nutrition and genes, which is, in essence, what you're, you're kind of saying, right, kind of figuring out also what nutrient is needed for the enzyme to work or to offload what needs to be offloaded or whatnot? Oh, absolutely. Yeah, I just want to make sure I mentioned nutrigenomics.

Dr. Bob Miller 10:42

Absolutely. But let's, let's give a good example of that. And that's why every one is unique. So one of the things we'll often hear is, you'll hear people talking about all the power of all these fermented foods, because they're good for their gut, and you know, eat all these fermented foods for some

Dr. Stephanie Gray 10:56

people.

Dr. Bob Miller 11:00

But if you don't make enough of the enzyme datamine oxidase, or you don't clear histamine, you can actually make yourself worse by eating all those healthy foods. You know, another good example is kale and beets that are high in oxalates. A lot of times you hear people that are oh, I'm not feeling well, I'm going to start to eat healthy. So it's like, well, let me do some greens. And I'm going to do, I'm going to do some spinach, and I'm going to make some smoothies and I'm going to, you know, mix this all up, and yeah, I'm going to be better. And then all of a sudden, they're like, What the heck is happening, um, worse?

Well, those foods are high in oxalates. If you have a bit of a leaky gut, those oxalates can leak in, and they can wreck havoc, they'll stimulate inflammation, you can actually get to the point that just being touched hurts because those oxalates are there. urination can be painful from the oxalates. So yeah, that's some of the interactions with with food. And sometimes food can be our best friend. Or for some people, it can actually work against them. So particularly with with histamine, if you have a histamine problem, nuts, some fish, even something made of fresh, it's in the refrigerator for a couple of days starts to ferment. So very, very common problem. So there's your there's your nutrigenomics. And then of course, there's all the environmental factors. Yes, yes, he put a lot of apps that we can do a deep dive into the environmental factors if you'd like to.

Dr. Stephanie Gray 12:23

Yeah, let's come back to that I there's so many directions, we can go with this. It's funny that you talk about eating healthy, because based on some of the other experts that I've interviewed, they mentioned January one, they see a lot more pelvic pain, like cystitis, kidney stones, right, because patients are trying to eat healthy, and then they end up with oxalate issues or whatnot, that it's not that those foods are bad, if you're listening, they just could be bad for you. If, again, you didn't inherit the genetic lottery source clearing out some of those. So I want to go back into find snip as well. So a snip is a I can't even remember single nucleotide polymorphisms been a while since I've said that. And as you mentioned, some snips can account for something as simple as you know, me having blue eyes, which isn't, you know, problematic, what not? Well, other snips can impact, again, the production of enzymes that impair gene function. And so your company has a test that actually looks for these snips.

So let's get into some of these, we have to bring up MTHFR variants, because that was one of the first variants that maybe that even you learned about that I think a lot of individuals came to me very concerned that they had right they thought it was just terrible. When in what I've learned is to look at all of the variants in totality, just having one MTHFR variant is not the end of the world, we need to look at all of the all the genetic variants, but for those individuals who may already know who are listening, that they have an MTHFR MTHFR variant. Can you talk a little bit about that? And what impact that can have? And then maybe let's go through, you've already mentioned there are oxalates snips, they're histamine snips, what are some of the other I guess I don't wanna say? Maybe the appropriate word is most common snips that you see that can cause problems. So let's start with MTHFR. And then let's, I'll just let you mentioned maybe your top five,

Dr. Bob Miller 14:06

well, the first thing I do because I get calls like that, oh my God, I've got MTHFR I know my first response to relax. You know, in my software, I look at the how often these things happen. And like the MTHFR C 677. Heterozygous happens around 47% of the people we look at, you know, I think we started talking about MTHFR when we started learning about genomics, and you know, quite frankly what it is it's an enzyme that puts what's called a methyl group on your folate. Now folate is important because that stimulates something called mTOR, mammalian target of rapamycin, which is the growth of new cells. So when a woman gets pregnant, you know if you don't have enough of that methylfolate really the won't get pregnant could have a miscarriage or deform baby because that mTOR is not going fast enough.

And it's also responsible for taking homocysteine put back into Muthiah, Nene, so that we can make something called Sammy accidental Muthiah Nene, which is a cofactor for clearing histamine clearing dopamine that also goes down to make your, you know, your glutathione is the homocysteine goes down through. So that methylation process is very important. But I think it's been way over emphasized. I agree. You know, as I said, I nearly died in my, in my early age, I don't have MTHFR. I've seen many people that have the MTHFR variation. They're 90 years old, and they're doing just fine. So we have to look at this in totality. If you look at a chart, you'll see that there's folate receptor sites, first, you could have problems there. There's, there's other things before you get to methyl Foley. And then after you get to methyl folate, there's an enzyme called MTR that takes homocysteine with methyl B 12.

And then there's something called mtrr, that puts a methyl group on B 12. So you've got methylated, B 12. So all of those play together. So I've seen people that have the MTHFR, C 677, they're methylating, fine, their health is fine. They have nothing to worry about. Now, if you got folate receptors, if you got MTR mtrr, maybe you've got some inflammation going on in the body from other reasons. There's an enzyme called ma t that takes Matthias into Sammy. That's why one of my favorite sayings is to 3d chess game played underwater, multiple factors. And I think when we try to take one enzyme, and say this is the bomb, that makes a big difference, I get a little concerned, I know there's like Facebook groups that all they talk about is MTHFR. And I'm thinking, What in the world could you be talking about? post after post, you know,

Dr. Stephanie Gray 16:50

and for those listening, right, if you've read or I'm sorry, if you've read about MTHFR that you've tested yourself for and you put yourself on B vitamins, there does come a point in time where you actually can be taking too much, sometimes you just need a little bit of the nutrient, right? You don't need to take that same high dose of whatever you're taking, you know, methyl folate or medical Valmy forever, right, your needs can change. And so I would highly encourage you. And we're going to talk about this at the end of the show today to find a practitioner who's trained in analyzing all of these snips in totality, like we're talking about today, because this is just just complex stuff. I'd like

Dr. Bob Miller 17:23

to talk a little bit more about methyl folate. Yeah, again, necessary for pregnant women I know. But particularly a lot of people don't know this. But you know, as we said, methyl folate stimulates mTOR if someone is exposed to the COVID virus, it's mTOR that replicates. So now's not a time to be overdoing your mTOR. So just a above Miller hypothesis, I think some of the people that are most risk are like bodybuilders who are taking the folate and the amino acids and the hormones to try to boost that mTOR because COVID hijacks mTOR. Now we're not saying this is a cure, don't get mTOR don't get COVID. I'm just saying if you have mTOR upregulated, and you're exposed, there's the potential that it could replicate more quickly. Now, the other thing we want to talk about is that, you know, there's so many inflammatory things going on right now, autoimmune disease is happening.

And there's a cytokine called aisle six, interleukin six. And I'm very intrigued by this. And it's our friend, unless it's not. So what I mean by that is that aisle six is there to kill a virus or help clean up a wound. But if it's overactive, that's when it causes mast cell activation, higher histamine, higher superoxide. One of the things into nutrigenomic Research Institute we're looking at is that I believe multiple environmental factors, particularly amplified and those with genetic weakness of higher levels of interleukin six. And that creates this cascade of mast cells. And we can talk about what mast cells are. But, you know, I'm sure when you started your practice, there wasn't many mast cell activation patients. Now you probably see a lot of it. And I believe environmental factors is what's doing. So my bottom line on that is that methyl folate will stimulate mTOR, which stimulates interleukin six leading to

Dr. Stephanie Gray 19:19

this kind of cytokine storm, I'm sure listeners have heard in the media about the cytokine storm that can happen with COVID. Aisle six is a cytokine. I just tried to kind of bring that full circle. So sure,

Dr. Bob Miller 19:29

and I believe multiple factors are causing interleukin six to be amplified. And that's why we're seeing so much mast cell activation. And then the final thing on MTHFR is if you don't have enough NADPH and we'll get into that, but that's basically what takes your oxidized and oxidants back into reduced in other words, after an antioxidant does its job it loses its electron needs to be recharged with something called NADPH. And if you don't have enough of that methyl Foley can actually make you more inflamed and anxious. So I can't tell you how many people in my health coaching have improved their health by saying, let's stop the methyl folate.

Or take it one or two days a week, when I see people that are inflamed, it's like, let's not do any methyl folate, get inflammation Calm down, and maybe do 600 800 micrograms one or two days a week later, as like, yeah, what do you mean, I have MTHFR. But sometimes that's all they need, if you're not pregnant or don't have other specific needs with with homocysteine. Sure, sure. Tony. Well, I grew up with, you know, I started out with the MTHFR, like everybody else, you know, started giving it and heard all these people I'm anxious and inflamed. Is i Whoa, what's wrong here? So it's important, but I think we've over emphasized it.

Dr. Stephanie Gray 20:43

What are some other genetic variants or snips that you commonly see that we should talk about

Dr. Bob Miller 20:49

today? Well, let me first say that, you know, I get referrals from physicians or work with physicians, you know, on people that are really struggling. So my demographics might be a bit skewed. Sure, sure. But those that are really struggling, here's my latest finding what I think is happening. Remember, we talked about the importance of antioxidants? Glutathione is the master antioxidant, yes. So it has a spare electron. And if you run out of glutathione, you're done. With these at its maximum and our 20s, you know, starts going down as we age and the lower it goes, the more inflamed you're going to be, the more the cells are going to disintegrate. So the glutathione donates that electron through glutathione. conjugation takes out toxins. So we tend to think the more glutathione the better. So a lot of functional doctors are saying, Take glutathione for some people, it's wonderful.

And other people are like, I'm feeling worse. And sometimes, you know, functional medicine doctors will argue and say, Well, that can't be you're just making this up. No, they're not. What happens is there's an enzyme called GSR glutathione s reductase. And Its job is to take that oxidized glutathione and put an electron back on it from NADPH. And recycling. One of the most common things I'm seeing in those that are really struggling, is they've got mutations on GSR or they've got mutations in something called N q o one, or G six PD that they don't make enough NADPH. And therefore, that oxidized glutathione doesn't go back to the reduced. Now it doesn't just sit there, it'll actually combined with oxygen to make another free radical called superoxide. And it's still not done doing its damage. It'll combine with nitric oxide, which is needed for circulation, and make something called peroxy nitrite, which is very oxidizing, which actually damages the cells, and also depletes your glutathione. So talk about the strangest thing, if you take too much glutathione at the wrong time, you can make yourself more inflamed and deplete your glutathione.

Now I'm not saying that does that I'm just saying if you don't take that oxidized glutathione back to the reduced and you're stuck there. So that's one of the most common things I'm seeing. I believe that genetic and environmental factors is impeding our ability to take oxidized glutathione back to reduced bleeding to this inflamed condition. And these are the folks that try everything. It's like I've been to every clinic and I've gone on every diet. Nothing's working. I take glutathione I feel worse. You know, I take other nutrients I feel worse. So for a lot of folks, we've got to make sure that GSR is working. Now the reason I think this is becoming more of a problem is because NADPH one of my favorite subjects, is what puts an electron back on the oxidized to reduced glutathione. And I believe environmental factors is up regulating an enzyme called NOx NADPH oxidase. And it's using NADPH to make inflammation. That's one of the most curious things I've ever seen.

NADPH will recycle your antioxidants help you make nitric oxide help you turn him into the storage of the iron had does all kinds of good things. But the NADPH oxidase enzyme will use it to make inflammation. Now, I'm very intrigued by this is one of the major areas that we're researching we're trying to teach practitioners on and that is that the NADPH oxidase enzyme is our friend. When we are faced with a pathogen, it says, whoa, we got a problem here. Let's make a lot of free radicals to kill this pathogen. We didn't do that we wouldn't live. But again, we're seeing all these people with mast cell activation, I believe environmental factors that we weren't exposed to 30 to 40 years ago. He's overstimulating the KNOX enzyme. And I've called this the NADPH steel.

Dr. Stephanie Gray 24:58

Yeah, that's all

Dr. Bob Miller 25:00

I made up. So the NADPH steel, I believe is when the NOx enzyme is upregulated by environmental factors, or even things like Lyme disease or mold exposure, we can talk about Lyme and mold if you want, because I think mold is a huge problem. So our NADPH is being used by this guy to make inflammation. Consequently, we don't have the NADPH to recycle our glutathione. And if we don't have enough NADPH, methyl folate becomes inflammatory. So you can see why I call this the 3d chess game, multiple factors, all of this has to be brought into effect, you know that there are no easy solutions of oh, I have MTHFR, therefore, take methyl folate. Oh, I'm inflamed. So therefore, I take glutathione he had got to look at a huge picture. But just to sum it up, I believe environmental factors are up regulating the NOx enzyme. Using up are NADPH not allowing us to recycle our glutathione amplified in those who might have snips on the GSR enzyme, or snips on something called NQF one or G six PD that they don't make enough NADPH those people are hit harder by environmental factors. So that's the big thing that I see going on.

Now the other snip that I that I'm finding to be very significant is nerf two and keep one yes, talk about those. Yeah, nerf two is a big one nuclear transaction factor in three, two, that's what we just call it nerf two. So nerf two will determine how long you live. Interestingly, in mammal studies, there's a relationship between the average age of the mammal and its nerve to activity. Fascinating, like turtles and elephants have high nerf to things that only live short periods of time have lower nerf to. So nerf two is an interesting enzyme, it signals the body to make glutathione use glutathione and recycled lithium. But it's also involved with making your NADPH. It's also involved with your phase one, phase two and phase three. It's involved with how we use our cholesterol, it's involved in quite a few factors.

And if we don't have enough nerve to activity, we're not going to detox we're not going to take care of those free radicals, we're not going to use our blood sugar properly. And you know we're in trouble. So there are snips that can happen on nerf to that we can. But to make it the 40 chess game, there's something called Keep one that holds on to nerf two. And it senses when there's a need for nerf to activity and releases it. The analogy I give is sometimes think of a sprinkler in the ceiling. So the sprinkler sits up in the ceiling and does nothing. Unless there's a fire, there's a water hose behind it. If there's a fire, the valve opens up, the water goes out and puts out the fire. If the heat center is not good, or the valve is sticky, the fire comes along and it doesn't respond. So there's a specific there's only one snip in keep one. And we have that in the software that when it's mutated, it's an upregulation, meaning it's holding on more tightly. And then there's another keep one mutation.

That's a downregulation. Now either one can be a problem, because if you don't release your nerve to to release antioxidants, you're going to be inflamed. But it's interesting. Everything is like a double edged sword. If you would happen to get a cancerous cell, your body attacks it and tries to kill it. That's what chemotherapy does. If you have downregulation of key one, the Nerf two could actually protect the cancer cell. So talk about a you know a double edged sword. We need the antioxidant protection to protect us from damage that causes cancer. But if you've got a tumor and your body's attacking, you don't want the nerf to protecting the cell. So one of my favorite sayings is Goldilocks and three bears. Not too much. Not too little. So nerf to keep one there's one snip on keep one and I believe that is significantly more important than MTHFR. And out of all the GSR enzyme, there's only two that are downregulation. Now what I've been very fascinated by is the fads enzymes, fatty acid Desaturase.

This is a big deal, because this is what takes the fats that we eat from our diet and takes them down a pathway to to make what are called protectants and resolvins that are anti inflammatory. If they're not working properly, we make arachidonic acid, which will then be pro inflammatory. So one of the things I see in people that just can't seem to get well, no matter what they try, they have a lot of snips in the fatty acid Desaturase genes. So those are ones I put to the top of the list. Now what I also find interesting is the interplay. So what we're finding is if someone doesn't take their oxidized glutathione back to reduced and they don't break down their fats. These are the people in real trouble. Because there's an enzyme called a locks, that I'll actually make something called 12, PT and 12 pt that stimulates Cox two, which is very inflammatory.

And these are the folks they just heard all over and nobody can figure out what's going on. These are also the people that if they try the ketogenic diet, they can't do it. Because they try to eat all these fats. And all their fats are just becoming inflammatory. And these are also people who have weight issues, because the they can't use their fat for fuel, so they crave carbohydrates. So it's not a that they're slaving away or don't have self control. They're self medicating with all these carbohydrates because they can't use fats for fuel. Now, if you remember, I started out by saying, I don't have any bad news. Because for these people, they may need to take things like amylase, protease, you know, other digestive enzymes, maybe some pancreatic enzymes with their meals to step in and help them break down their fats. I said no bad news. So if you're if you don't break down your fats, there's ways to step in. You can't fix the fads genes. You know, sometimes I tell people, we have good news and bad news. The good news is we can compensate the bad news is we can compensate.

So you can't fix it. But if your fatty acid Desaturase is are not doing their job properly, you just step in and help. Now I'll share with you some of my most recent research is the first time I've talked about this on a podcast. So this is where this information is premiering. Okay, nitric oxide. If you you know, Google nitric oxide, you will see hundreds of websites you know, touting look, this won a Nobel Prize in 1991. Three scientists won an award because this dilates the blood vessels, and therefore, it's related to cardiovascular health. All of that is absolutely true. And that is done by an enzyme called enUS, endothelial, nitric oxide. The more that the better. So that's why, you know, people will carry with them nitroglycerin because it'll boost the NOS.

That's why we use Viagra and Cialis for men with erectile dysfunction because they need their blood flow for the erection. However, there's an enzyme called ionos inducible, nitric oxide. And again, this guy is our friend, unless it's not. What I mean by that is when we have bacteria, virus, or parasites, i na says we got a problem here. Let's make extra nitric oxide to make inflammation to kill these pathogens. Now, again, without that, we die of infections, especially like Epstein Barr. If somebody doesn't have ionos, Epstein Barr kills them. So we need this ionos to kill the pathogens. So it's not all bad. But again, I go back and I look at water environmental factors that might be overstimulating. I know us. And in our research, we found some very fascinating things. BPA from plastics, stimulates lightness. We're gonna look back someday Dr. Gray and say What were we thinking?

Dr. Stephanie Gray 33:11

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I discovered this feature almost immediately after installing Meyer Dr. At home when the indicator light went from green to red. It got me wondering why the air was so bad and I did some digging. It turned out there was a problem with my furnace. After it was fixed air Doctor sensor immediately turned back to green. And I not discovered the issue with the help of their doctor we could have ended up with much greater problems. I often recommend the air doctor to my patients dealing with mold toxicity of course I always recommend they remove themselves from the mold exposure as soon as possible. But I understand it takes time to remediate the home. So in the meantime, as well as on an ongoing basis I recommend they get air doctors running in their homes. One of these machines would be a great Christmas gift for a loved one stopped by the integrative health and hormone clinic if you'd like to see different sizes or visit the bonus tab of my website, your longevity blueprint.com to find a special For $280 off the 83,000 using code Gray 15. That's capital G ra y 15.

And watch for even greater promotions during Black Friday and Cyber Monday but you must use my link which we'll post in the show notes ever drinking out of plastic ever, like putting everything was at food, so many food products are stored in plastic. I talk a lot about BPA on the podcast because of the hormone disrupting component because obviously have a hormone clinic I see a lot of women in midlife, plastics can cause as you're talking about more problems than just with your endocrine system.

Dr. Bob Miller 35:37

Sure it stimulates the house, then aluminum, you know, we're gonna look back some day thinking about why are we smearing aluminum chlorohydrate into our armpits and and some of the other sources of aluminum. And then also one of the things we're really deep into is lipid polysaccharides. They stimulate ionos as well, we believe we're still researching it, but there are evidence based nos two enzymes that we believe are gain of function. And what I've been observing and what we're researching is when people have a lot of mutations on these nos two enzymes, the eye nos is upregulate. We can't find the literature that confirms it yet. But when you look at the literature, what these things cause, like, you know, I have X si nos is behind inflammatory bowel disease, and rheumatoid arthritis. As we're researching and observing, we're seeing a lot of people who have inflammatory bowel disease, and rheumatoid arthritis have a lot of these nos two mutations, which we believe are upregulation.

So that's some of our some of our exciting research right now. And then finally, there isn't a gene called aisle six enzyme that actually stimulates the aisle six, and there are mutations that are upregulation of that interleukin six. And the final one, the final two that I think are really important, is MQL. One and G six PD and Q one take something called NADH, which is energy, but turns it into an ad plus. And that Ennedi plus is part of your DNA repair, making of Iran oxidants making NADPH. And Q one also helps clear superoxide. So again, we see people who have a lot of mutations and Q one and there's only two of them that are evidence based, those people are having trouble. And g six PD, that's also how we make NADPH, amputations and those lead to a lot of inflammation. So those are just off the top of my head, those are the top ones that I think are much more important than MTHFR. Not that that's not an issue. But I think there's others that wreck a whole lot more havoc in the body, when they're not functioning. You're worsened by environmental factors.

Dr. Stephanie Gray 37:45

Okay. And well, I want to get to environmental factors next. But I want to comment on a couple things. So you alluded to a software and so I want to make sure the audience understands what software we're talking about. So your company, you call it a

Dr. Bob Miller 37:57

lab to call No, we're not a lab, we do a genetic test with the we made that we had custom made for ourselves. And then the lab is Rutgers. It's called Brooks at Rutgers University. They're the lab that extracts the DNA. Okay, so we have to have professionals who are licensed in order to Sure. Then I wrote software that takes that data from Brooks at Rutgers and runs it into software, it just displays the mutations and organizes them. Yeah. So that the software is for professionals only. This isn't something I know there's stuff you can go to online where you can load up. My software is only for for doctors, nurse practitioners, you know, someone who actually has a practice and has some kind of licensure or certification. Because it is complex. I think when people try to do this on their own, it's just confusing.

Dr. Stephanie Gray 38:47

And just so the audience understand. So if you've done 23andme testing, or ancestry, or testing whatnot, you can find like Mike, Dr. Miller was alluding to sites online where it will interpret some of your genes, or it'll essentially plug them into a little report mean a two page report telling you you have an MTHFR variant or vitamin D receptor variant or whatnot, what we're talking about is a whole nother level higher, right? So I don't even know how many pages your reports are like 6070. I don't even know how many pages there are these days, they're very long. So all of these variants that he's alluding to today are going to be tested. If you just do a 23andme test and you log into your 23andme portal, they're not going to display any of this information. So this is taking the analysis a whole nother level higher. And it does have Oh, go ahead. So let's

Dr. Bob Miller 39:37

just say 23 And me, if someone has an old 23 levers and version three or four, there's good data on their, their version five, which they upgraded, I think for better ancestry or other things. from a functional standpoint, it's almost useless. So that's why and I'm not criticizing the report. I mean, they made it better in other ways. But for functional data, they took most of it out That's why I made my own test called your genomic resource that looks at 225,000 snips. So doctors order the kit for the patient, they send it to Rutgers, Rutgers in their CLIA lab, take the data out, send it back to my software company, who organizes it and gives a printout to the doctor and the patient a very thorough analysis. Yeah, and what we're doing, we're really excited about this. We've just added dynamic messages. So I mean, I this is all I do.

So I'm a geek, and this is all I do. But for the busy doctor, it's like this is way too much to learn. So what we're doing is we're putting logic in, and we're gonna have new reports that it'll connect the dots. So it'll tell the doctor, you know what they've got GSR. Plus, they also have nerf two and keep one that makes this potential that'll be helpful. Yes, so we're gonna have all kinds of pop ups. And so it'll be like me sitting there with a doctor saying, Hey, look at this, you know, say, for example, you've got, you think you've got mast cell activation. And you've also then got trouble with the Mao enzyme that breaks down the histamine. You know, connect those dots for the doctor, because again, everything connected, you can make a decision based upon one snip, or one enzyme. They all interplay, it's, I often give the analogy, it's like a spider web, you touch one piece, and the rest gets affected.

So you got to look how they all interconnect. So in my software, and we don't make decisions based upon the snips because he never made a decision based upon the snips. The doctor has to make decisions on the snips, the labs, and the symptoms. So for right now we put in the Great Plains, you're in organic acid test, and their patient fills out like 150 Questions survey. So if you have a lot of snips on, say, like the HMT enzyme that breaks down histamine, and they report that they've got spring and fall allergies, and they get hives all the time, well, then it's like, oh, I

Dr. Stephanie Gray 41:57

think connect the dots. Yeah, yeah. So you

Dr. Bob Miller 41:59

should never make a decision just based upon the snips because they may not be expressed. I often say the snips are like somebody waving at you think about looking here. But if they're not expressing the labs or the symptoms with it, well, then it's probably not all that serious. So anybody who says you should do this, because PIP on these on that one snip, I think is doing a disservice. It's much more complex, you need a trained health professional, who looks at snips, labs symptoms together to make a clinical decision. And then also you got to do it in the right order. You know, one of my favorite sayings is, when the house is burning down, you don't paint the walls and mow the lawn. So if people are in a lot of inflammation, maybe now's not the time to start doing some being heavy metal detox, or your you know, start boosting energy production. Let's put out that fire.

Let's knock down those free radicals. boost the in oxidants. Take our time, one of my favorites ages, I'd rather be a little too late and too soon, knock down the inflammation, then do a little bit of cleanup, then do a little bit of building. You know, just think about is that silly analogy. But if a house is burning down, you don't call the carpenters. You don't call the cleanup crew you call the fire department. And you know, this is so obvious, but yet sometimes we don't think about it. It's like, Oh, I'm tired. What can I do to boost energy, we might be tired because the cells are inflamed. And if you try to do things to boost things up, you may make things worse. In my software, we have what's called the pyramid where there's a bottom row, it's all the things that create inflammation. The next row up is how you make in oxidants. The next row up then would be your Phase Two detox pathways. You got to do things in the right, order.

Dr. Stephanie Gray 43:55

So good, so good. I have to go back quickly. If you could quickly comment on CMT variants that was those are variants I mentioned in my book because I have through various times in my life I have kind of unfortunately been stuck in a more of an adrenaline storm. I couldn't kind of clear out the adrenaline as well and and now I do know some nutrients and lifestyle changes that I need to plug in, you know to help. Can you focus a little bit on CMT for a minute here and the importance of looking at those variants

Dr. Bob Miller 44:21

catacomb amino methyl transferase and and what CMT does. It uses Sammy as a cofactor to clear out excess dopamine excess histamines, I'm sorry, excess estrogens, and other catecholamines. So if that's not working properly, the dopamine can go too high. Now, dopamine is what you know, gives you drive but on the other hand, if the dopamine is too high, you're not a fun person to be around. And then additionally to that the the dopamine can stimulate cytokines and not only to see you MT come to play in there. By the way, if somebody has Clostridium, there's an enzyme called DVH dopamine beta hydroxy. That turns dopamine and norepinephrine. So if somebody has got clostridia that can be impacted.

And you can also have mutations on DBH as well. But back to CMT. One of the things that's fascinating is that if you don't have enough, Sammy doesn't matter whether you have mutations on CMT or not. So that's why, you know, although I make a genetic report, I often say you can't make a determination just on the enzyme. You could have no mutations at all on CMT. And if you don't have enough, Sammy because of MTHFR and other things, it's like having a brand new car without gas. It sits there and does nothing. Now there's also things that will encourage enzyme function, and discouraging estrogen inhibits CMT, testosterone strengthens it. And then there's also things called tyramine like and things like cheese that will inhibit CMT. And then, of course, you can have mutations on CMT that lower the function, and also quercetin, you know, a lot of people are taking quercetin for histamine, quercetin will also inhibit CMT. So that's one of the things we're putting in the software.

As people are looking at nutrients, a little message will pop up. This person has a lot of CMT. Maybe you want to not consider quercetin. So again, quercetin herb nutrient, unless you've already got impaired CMT function. So think about what's happening. You know, we are living in a sea of estrogen with all these plastics. So estrogen is going up, particularly in boys, testosterone is going down. So if you talk to college professors, what do you hear about the boys fragile, they get it with glee. They need safe spaces in coloring books, you know, because they're afraid it's not their fault. You know, I'm not being critical. Yeah, but is there their testosterone goes down and their estrogen goes up. They're going to have less CMT function. Additionally, there's an enzyme called histidine decarboxylase, that will turn the amino acid histidine into histamine. And testosterone calms that down. So particularly for boys, if their testosterone starts going down, besides all the other benefits, histamine could go up, dopamine could go up. And, again, this is a purely hypothetical speculative, but you know, turn on the news for 10 minutes. And it's like what in the world is happening to everybody? People seem to be getting angrier, quickly, condemning everyone violent. Again, Bob Miller speculation. But I have to wonder if environmental factors are not playing a role in the higher dopamine and the higher histamine and, and that's why we're seeing people becoming irrational, very irrational.

Dr. Stephanie Gray 47:48

I get asked all the time, what's one product that I just can't live without when it comes to maintaining my own health and longevity? And my answer is something you've actually heard me mentioned on several episodes. It's called mitochondria complex, and it's pretty much the Cadillac of multivitamins, and it's packed with antioxidants, including three key players acetyl, l carnitine, Alpha Lipoic Acid and an acetyl cysteine. Think of a steam engine that requires coal to be continually shoveled into the furnace to power the train forward. Acetyl l carnitine. Does that for your body by shoveling short chain fatty acids into your cells to provide your body with energy? This is an absolutely essential task to keeping you running. However, what's a byproduct of fire? You guessed it smoke. Unfortunately, in this analogy, smoke from fire equals free radicals. To combat those free radicals. Other antioxidants are needed and that's where alpha lipoic acid and and acetylcysteine come in. Together they scavenge free radicals and help boost and recharge glutathione the most potent antioxidant in the body. To top it off mitochondrial complex also contains a little bit of green tea extract, broccoli seed extract with sulforaphane and even resveratrol.

Research has shown that when athletes and individuals that are under stress begin taking this product they are less likely to get sick as they're giving their body what it needs to conquer those stressors who doesn't need protection from stress and cellular damage at this time? I certainly do. I take this product every day. If you're interested in learning more about how mitochondrial complex can help support you living a longer healthier life check out my blog post on why antioxidants are important found at your longevity blueprint.com forward slash why dash antioxidants dash r dash important for in chapter four of my book Your longevity blueprint to get 10% off our mitochondrial complex just use code energy when checking out at your longevity blueprint.com Now let's get back to the show thank you for going over all those all those variants I could in the podcast now but I want to talk about environment. So let's move on to environment but we've jam packed this already. So in my book if you've listened at all to me talk about variances while you've heard me say this I didn't coin this term. I'm not the first person that has said this but essentially the saying our genetics loads the gun but environment pulls the trigger means in part that the environment can be the straw that breaks the camel's back.

Right. So back to my book, sorry, trying to organize my thoughts here. I mentioned just an example in chapter three, that you couldn't be managing your genetic variants while until you travel, right. But then you're stressed out, you're sleep deprived, you have radiation, maybe from the plane ride, electromagnetic chaos, everybody's on their phones, then you you know, you're sleeping in a beach house that may have mold exposure, right? So that then you have alcohol if you're having margaritas or whatnot. So suddenly, all of these, all of these variants, unfortunately, can now be expressed Can you can, based on the lifestyle in that moment, this could set off a cascade of events that you kind of feel like you're starting to fall apart. And so that's an extreme example of how Yes, you may have the genetic variants, but now the environment of the stress of this vacation or pulling the trigger, per se. Hopefully I explained that decently.

Dr. Bob Miller 50:50

Great job, you got you nailed it.

Dr. Stephanie Gray 50:52

So let's talk about what you have found. You've already mentioned BPA aluminum LPs, what are some environmental factors that are negatively going to impact our genetic expression?

Dr. Bob Miller 51:04

Well, my people won't be surprised by this. But I'm very concerned about EMF electromagnetic field. Me too. Yeah. And this isn't just, you know, conspiracy theory. I mean, if you go on the internet, and you start looking at the literature, because everything I try to say I make sure it's based upon literature, not just speculation, or I heard somebody say, and there is a ton of literature out there, on how electromagnetic fields, increase our free radicals, and decrease our antioxidants. One of the major pathways, there's an enzyme called CAC, and a one C, or calcium voltage channel. And what that does, it pushes calcium into the cell. And that's a good thing, unless it's excessive. And if that calcium voltage channel is weak, because it's mutating, and then you're exposed to electromagnetic fields, now, let's think about the history of man. It's just a blip in time that we've been exposed to all these cell phones.

So we have our cell phones on us, we have our Wi Fi at home, we might be streaming our video to our television set, we get smart homes where we tell the drapes to go up or down. Alexa is listening to us, and then you live near a cell tower. And so from a historical perspective, we're in a way unchartered territory. And there is some concern that this EMF, it's happening to all of us, but again, those who have genetic weakness, and I've seen this hundreds of times, people who have genetic weakness in their calcium voltage channels, particularly if they get a mutation from both parents. EMF has a profound effect. They're not making it up. You know, they feel funny when they hold a cell phone. And I think we're going to look back someday, particularly, you know, I'm glad to see you've got a wired earbuds there.

But I think we're gonna look back someday and say, What were we thinking, putting little transmitters into our ears? And then you know, we're streaming our video. So I think for the people who are listening, there's a couple common sense. Don't charge your cell phone next year bed. Every once in a while you hear about teenagers that put their cell phone under their pillow. So they hear a text message. It's like, yikes, you know, your cell phone is constantly communicating back to the tower. So even when you're not speaking, it's doing that. So I think we need to do some common sense things on on EMF, Miller households may be a little crazy. But a couple months ago, we pulled the plug on Wi Fi. We just wired everything. I personally sleep in a sleeping bag called 5g Block wave. This made of silver threads, that at least while I'm sleeping, I'm not getting ready. You know, I'm a bit of a dinosaur in my office. wired mouse. Yeah, yeah. wired keyboard. This internet connection is wired.

So I think we need to do some common sense things. So I believe I heard one doctor say one time that we believe EMF is going to be like smoking was back in the 1950s. And I believe we're gonna see some negative effects from that. gallon, of course, is glyphosate or Roundup? You know, again, we was touted that this was safe and, and I'm no expert. But if you listen to Dr. Stephanie Senath, you know, from MIT, she makes some good arguments that this is impacting our, our glycine, which is affecting us in many ways, impacting the the heme cycle. Then as we discussed, the plastics, the xenoestrogens of those, you know, male frogs are getting ovaries, something's up here. And I'm in Pennsylvania, and I saw an article that you can't find one waterway in Pennsylvania, that doesn't have plastics in it, you know, micro plastics,

Dr. Stephanie Gray 54:35

we've destroyed the earth.

Dr. Bob Miller 54:38

And I'm not some tree hugging hippie here. But you know, we have to be realistic in our, in our, you know, in what we've done, we really have and then you know, the other one I think we're gonna look back on is what were we thinking, giving the animals growth hormone so they get fatter faster. Oh my goodness, that stimulates mTOR that we can do toffee G mTOR. Is the growth have new cells and it doesn't care whether it's a healthy cell or cancer cell, it replicates it. And then that weakens autophagy the ability to take things out. So I'm sure you're seeing women getting younger and younger with age spots. You know, when

Dr. Stephanie Gray 55:16

I was saying getting younger and younger, now I have some myself. Yeah. Yes, yes, I am seeing those

Dr. Bob Miller 55:22

are seeing women younger having

Dr. Stephanie Gray 55:23

at that age.

Dr. Bob Miller 55:26

So the and that's those age spots is when autophagy is not working as robustly as it should. So we've done so many things to stimulate mTOR. And then we have the volatile organic compounds are making our homes tighter. I personally think we're gonna look back someday and say carpet, why did we do that? Because when it's new, it's the volatile organic compounds will. And then finally, I believe that mold is getting much stronger. I don't know what's driving it. Some people say and I don't see any papers on this, but it's speculated that EMF might be making mold stronger. I don't know. It may. I don't want to say that that's happening. That's speculation out there. But I just see so many individuals that are so sick because they're exposed to mold. And those mycotoxins stimulate interleukin six, we're researching, but I think they also stimulate ionos. But I can't say for sure.

But so many individuals, the cause of their their illness is mold exposure. And you know what happened? He talked to people you have mold in your house. Oh, no, no, no, we don't have any mold. Everything's good. Well, did you ever get your ducts cleaned? Well, no, no, we never did that. And you know, some people have their you know, their, their ductwork is full of mold. Or they may not even see Miss visible mold, but it might just be in the air. You know, if you had a a water leak five years ago, toilet overflowed? Somebody, the tub overflowed. Water came in, that mold can be hidden somewhere, and you don't see it.

Dr. Stephanie Gray 56:56

Yeah, by the time you see it, it's bad.

Dr. Bob Miller 57:00

You know, we recommend people who like the Great Plains, you know, mycotoxin test and people are done how much mycotoxins they have. And I believe if you are filled with mycotoxins, there's no natural remedies, there's no medical remedies that are going to get you well, you've got to get out of the mold. Because if you're living in mold, I mean, you might be able to take pain down a little bit, you might be able to do a little something. But you'll never get well, if you don't get out of mold. And then if you got mold, any EMF or if you've had Lyme disease, that's the trifecta, so to speak, the triple threat that really puts people in a hurtful situation. So there's my there's my top environmental, lots, lots

Dr. Stephanie Gray 57:41

lots to unpack there. Well tell us for listeners who are maybe diving in for the first episode today and very overwhelmed. After this episode, how can they find a practitioner who you have trained, who uses your software, who can run the appropriate, you know, analysis and interpret those results. So tell us about yourself where listeners can find and connect with you, your company and how they can find that practitioner familiar with what we're talking about today? Well, if somebody

Dr. Bob Miller 58:05

wants to talk to us here, our website is to ill health.com Tree of Life health. So T isn't Tom O is an Oscar Ellison, Larry tll health.com, our phone number is 717-733-2003. But of course, you know what you're doing on this stuff as well. So they can contact you and you can run the test and do it for them. And then if you go to our website, functional genomic analysis.com. There's also a list of other trained individuals. So if someone would like to go see somebody near them, they can do that. And also, you know, if someone is listening to this, who is a practitioner, we do have online courses to train them how to do that. We also have conferences now and again. And what we do is the first couple of classes people can take for free, because this is not for everybody. This is not for the faint of heart.

This is for the serious practitioner who wants to delve in. So I want to be clear, this software does not give you a one page report that says do this, you've got to look at it, you've got to analyze it, you got to make some decisions, we actually now have it that the practitioner can make their own custom product, they can actually work with personalized nutrients and make a bottle for the individual. And we're having upgrades on that. So if you go to functional genomic analysis comm you'll see there's a certification course. And the practitioners can take the first couple classes for free and decide us for them. Because some people are like, Oh my gosh, this is the coolest thing I've ever heard. And others will say no too much work, not doing it. And that's okay. You know, we don't want anybody doing it who's not interested. Then if they want to finish the certification course, if they put in Dr. Grey, Dr. Gra y, they'll get $100 off the course. Then at the end, they they submit some case studies they've done and of course, this doesn't qualify for anything that you're not licensed for. This does as you take a certification course. In fact All genomic.

So there's a couple of the handful of lay people who say, You know what, I'm not a practitioner. But I just think this is way cool. I'd like to know it. Okay. But I mean, obviously you can't practice. But if you just want to know it, for your own knowledge, because you think it's cool they can, they can take it as well. So that's, that's your best bet, take the certification course. Or if somebody does have some knowledge, we give a free trial of the software. So they have to put in that they're, you know, licensed or certified practitioner, they have an office, again, this is not for the public, then we open up an account for them. And if they have an old 23andme, they can load that up for free and try it, the genetic test is 199, the doctor pays. And so we try to keep it very reasonable. And the doctors that we have using it are thrilled because they're getting answers they didn't get before. So if someone's inflamed, unless you look at the genomic, you don't know if it's because maybe the iron is being turned into a free radical, you know, maybe aisle six is upregulated. Or maybe that's all fine, and you're just not making an oxidants. Without that roadmap, you're kind of in the dark, I mean, sure, you can give me an oxidant, you can give some glue to file. But if you want to be a precision practitioner, be in where specifically the problem is.

And I didn't mention that, you know, iron can be a bad boy, without iron. Life doesn't exist, we needed to carry our oxygen, put a fire in his excess and not carry it around properly. It's one of the nastiest free radicals there is, it will chew you up and spit you out if iron is not carried around properly, or it excess. So that's another way that we can make access information. So knowing that gives the practitioner the knowledge they need of how to very specifically, and the key we like the word we like to use the key word is personalized. I think we've got to get away from pill for the ill. And personalized, you know, for example, somebody could be dealing with arthritis, you know, you typically what do we do for arthritis, you know, the older rule books would say do this, when the doctor does this, you can see 10 orthopedics in a row 10 different protocols. And along the lines of protocols, we've also made a professional line of supplements, called functional genomic nutrition, again, not available to the public, you won't find it if you Google it. But again, it's for the doctor that for each of the pathways, there's a nutrient that's made, and then the doctor can can recommend.

So we're trying to be the leader in functional genomics and getting away from the pill for the ill treating the disease, getting to the function that might be impaired. And again, it could be environmental factors. It could be get them all out of your house, don't sit next to your Wi Fi. All right, stop eating ketogenic diet. Don't do that spinach. And by the way, I'm not against spinach. But if somebody's got an oxalate problem, that's been ages, the problem, or if you've got a gut inflamed, I really get a little concerned that some of these formulas have all this glutamine and glutamine can turn into glutamate. Yeah. So you know, a lot of times the things we think are just my kryptonite. Yeah, that's the that's the big overview. Any other pathways you want to go down here?

Dr. Stephanie Gray 1:03:06

No, I think this is this is incredible, the interview kept getting better and better and better. So I think as you mentioned, the, as a practitioner, really diving into functional you know, I should say nutritional genomics is not for the faint of heart. And I though with just this this small amount, I would say that I know I I mean, this is deep work deep diving into a lot here. But I will say that this has really provided hope for a lot of my really complex patients, right? This was the layer that I even through my fellowship program. We weren't talking about barely any of this, you know, years ago. So companies like you, and I thank you for coming on the show because companies like yours are really paving the way to help patients and then providers know that if you know those patients haven't inherited like we opened the show with a genetic lottery, right? They can still live a long healthy life. So

Dr. Bob Miller 1:03:51

know your genes is not your destiny.

Dr. Stephanie Gray 1:03:53

Right? Right. I have to ask you your top longevity tip. So let's end the show with your top longevity tip.

Dr. Bob Miller 1:03:59

Well, from something to do would be hydrogen water. Very simple. You know, it's a little tablet you drop in a glass of water, it fizzes and it knocks the hydrogen loose, and that hydrogen will neutralize free radicals. It also turns on your antioxidants. So from a something to do, and then also from you know, a lifestyle, try to limit your exposure to EMF and then work on that nerf to them. If that's weak, you know, do some things and there are nutrients you can do to support

Dr. Stephanie Gray 1:04:26

nerf to mention just a few of those and we'll wrap it up.

Dr. Bob Miller 1:04:29

Oh, well sure. Milk thistle is one one that people haven't heard of is called par actin, which comes from Andrew graphis. We actually for doctors, we made a product called nerf to support that we studied for a long time looked at all the things that support nerf to resveratrol. So it's the basic premise is to stimulate the nerve to activity, so that kicks in properly. But even having said that, you have to be careful not to do too much of it. You can actually make inflammation so I generally start out by supporting nerf to one to two Two days a week.

Dr. Stephanie Gray 1:05:00

Wonderful. You are a wealth of knowledge, a wealth of knowledge. Thank you so much for coming on the show. For all the listeners, be sure to check out the show notes. I'm also going to post a link to in the show notes. I will post I guess a list, I should say of all the variants that that he mentioned. And that's something that you can those variants you can look for on your nutritional genomic analysis. So thanks again for coming on the show. Have a good week.

Dr. Bob Miller 1:05:21

Well, pleasure is a lot of fun, be happy to come back anytime. Thanks.

Dr. Stephanie Gray 1:05:28

Wow, again, what a complex topic we discussed which Dr. Miller made more fun and easier to understand. If you're interested in looking at your functional genomic analysis, call the integrative health and hormone clinic to pick up a test kit or if you've previously completed 23andme and have version four data or below, we can still use that data and run it through Dr. Miller software program. If you want to take his certification course be sure to use CO Dr. Gray for $100 off and we'll post the link to that in the show notes. In conclusion, as Dr. Miller mentioned, your genes are not your destiny. To minimize the negative environmental effects on your genes. Try to reduce your exposure to glyphosate, aluminum, BPA EMFs and mold and find a skilled provider who can interpret your nutrigenomic report and recommend personalized nutrition and supplements. Be sure to check out my book your longevity blueprint. And if you aren't much of a reader, you're in luck.

You can now take my course online where I walk you through each chapter in the book plus for a limited time the course is 50% off, check this offer out at your longevity blueprint comm and click the Course tab. One of the biggest things you can do to support the show and help us reach more listeners is to subscribe to the show. Leave us a rating and review on Apple podcasts or wherever you listen. I do read all the reviews and would truly love to hear your suggestions for show topics guests and for how you're applying what you learn on the show to create your own longevity blueprint. The podcast is produced by the team at counterweight creative as always thank you so much for listening and remember, wellness is waiting.

The information provided in this podcast is educational. No information provided should be considered to be or used as a substitute for medical advice, diagnosis or treatment. Always consult with your personal medical authority.

Transcribed by https://otter.ai