Reduce your inflammation and pain levels while improving your overall health and longevity by using peptides, nootropics, and antioxidants. I’m joined by Dr. Neil Paulvin to talk about how he uses these methods to optimize his patient’s health.
Listen to the Episode
How to Improve Mobility
- Alternating between joint-specific exercises, such as Kin-stretch, and using a massage ball
- Full-body stretching, such as yoga poses like cat-cow, pigeon, scorpion
- Using a foam roller
About Dr. Neil Paulvin
Dr. Paulvin’s goal with all of his patients is to optimize their health in the first 60-minute visit. He is Board Certified in Family Medicine, Anti-Ageing and Regenerative Medicine, Osteopathic Manipulation, Functional Medicine, Craniosacral Therapy, and Medical Acupuncture.
He has helped top executives, Olympic athletes, top trainers, and celebrities optimize their health. Dr. Paulvin features in the NY Post, Nutritious Life, Fasting MD, Ari Whitten, and many other publications and podcasts.
Dr. Paulvin’s practice is in Manhattan. He also serves clients in multiple states including Florida and California over telemedicine. Dr. Paulvin uses traditional and alternative treatments to help his patients.
Patients see Dr. Paulvin for his expertise in Biohacking and Health Optimization. In addition, he specializes in helping his patients with hormone optimization, Peptide Therapy, Nootropics, and natural options for pain relief.
What Exactly Peptides Are
Dr. Paulvin begins by explaining what exactly peptides are and how they’re used to improve our health and longevity. Peptides are beneficial to so many different aspects of our health. Anxiety and depression benefit particularly, because of the connection between the gut and our mental health.
It’s possible to use peptides in combination with your prescription medication as well, Dr. Paulvin explains. His method is to use a lower peptide dosage and go slow – it’s better to be cautious.
As we age, our thymus gland activity reduces. This is one of the reasons we should supplement with peptides – to help boost our immune system. You can also use peptides for weight loss. Dr. Paulvin provides some examples of how this, too.
Mitochondrial Dysfunction and Inflammation
As you can see, peptides have a role in our health and longevity. Dr. Paulvin explains what mitochondrial dysfunction is and how we can use supplements and antioxidants to improve it.
Dr. Paulvin talks about the antioxidant he uses, including Nrf2 and PQQ, and some of the administration methods. He shares how to use each of these methods, including his preferred method of IV treatment.
Finally, Dr. Paulvin explains how inflammation impacts our overall health and longevity. It’s essential we control our body’s inflammation using the methods he describes. Dr. Paulvin also recommends improving your mobility to reduce your inflammation and pain levels.
Have you considered adding peptides to your wellness routine? Call the Integrative Health and Hormone Clinic today and schedule your first appointment at 319-363-0033.
“Peptides can be combined with prescription medication. I’d rather patients go with lower doses and go really slow. Serotonin’s one thing, but too much serotonin can get them in trouble. That’s the one thing I’m cautious about.” [9:14]
“Right now, we’re finding more and more that we used to focus on cholesterol and everything else to take care of your body. You need to take care of your mitochondria because it takes care of you.” [19:37]
“Mobility is not just about your shoulder hurting. It could actually affect your diaphragm, the nervous system, then it will affect the lymphatic drainage system, then your body’s ability to detox. It’s a snowball effect.” [28:26]
In This Episode
- What peptides are and how they’re used [3:30]
- How to use peptides for anxiety and depression [5:00]
- What happens with the thymus gland as we age [14:30]
- How to use peptides for weightloss [15:30]
- What mitochondrial dysfunction is [17:45]
- Why we need to know about Nrf2 [24:00]
- How to use PQQ antioxidants [25:30]
- How inflammation impacts our health and longevity [30:00]
Links & Resources
Get Your Free Energy Guide from Dr. Paulvin
Additional Resources Mentioned
Dr. Neil Paulvin 0:04
inflammation affects everything at this point is huge. Now in brain health, we know it affects weight gain. We know that it affects just energy levels in general, it's gonna affect the mitochondria. It could be from the food you eat if your inflammatory foods you're eating sugar and gluten every day, so it affects every part of your health. It could be from what you're eating, what you're eating, not exercising stress obviously can boost your inflammatory levels. So that's why you want to do some combination again, mind body, exercise, supplementation peptides and kind of have that program.
Dr. Stephanie Gray 0:39
Welcome to the longevity blueprint podcast. I'm your host, Dr. Stephanie gray. My number one goal with the show is to help you discover your personalized plan to build your dream health and live a longer, happier, truly healthier life. You're about to hear from Dr. Neil Paulin. Today he's going to share his wealth of knowledge on peptides nootropics and share a different twist on mitochondrial health. Let's get started.
Welcome to another episode of The your longevity blueprint podcast today I have Dr. Paul Heyman. The goal with his patients is to optimize their health in the first 60 minute visit. He's board certified in family medicine, anti aging and regenerative medicine, osteopathic manipulation, functional medicine, craniosacral therapy and medical acupuncture. He's helped top executives, Olympic athletes, top trainers and celebrities optimize their health. Dr. Pavin has been featured in The New York Post nutritious life fasting, MD, Ari Witten and many other publications and podcasts. Dr. province practice is based in Manhattan. He also serves clients in multiple states, including Florida and California over telemedicine. Dr. Pavin uses traditional and alternative treatments to help his patients. Patients see Dr. Pavin for his expertise in biohacking and health optimization. In addition, he specializes in helping his patients with hormone optimization, peptide therapy, nootropics, and natural options for pain relief, which we're going to get into today. So thanks for coming on the show. Welcome, Dr. Robin.
Dr. Neil Paulvin 2:06
Thanks for having me. I look forward to
Dr. Stephanie Gray 2:08
so tell me your story. How did you get interested in regenerative medicine I too am board certified in anti aging regenerative and functional medicine. So tell me how you got interested in that.
Dr. Neil Paulvin 2:17
It was kind of just the natural progression. I started doing family medicine I do. I did sports medicine. And then back then it was you started having some things became really big and PRP became a little bit bigger. And then I was doing patients also, I somehow got a lot of patients who had either chronic fatigue or fibromyalgia and the basic stuff, traditional prescription just weren't cutting it. So I started doing deep dive into acupuncture and then two hormones and then it just kind of go to more conferences. And you know the same thing, either, oh, this works. And that works. You talk to other doctors and you just kind of keep going and going. And now my practice is kind of transfer more into cutting edge stuff, as opposed to mixing with some hormones. So doing a lot of the fibro patients, I also help people who want to become like a few who want to be always be an 11 on a scale of one to 10 that's kind of like my clientele, they always aren't happy, they want to be better. It's a good thing.
Dr. Stephanie Gray 3:09
I like that, I like that I've never heard that. I want to be an 11 I want to be a 12. That's great. So I would agree. And I think it's exciting, like you said to be on the cutting edge be more progressive. And so I want to talk about a lot of those therapies because I think my guests are very interested in those. So one of which is peptides. Now I have had some speakers in the past talk a little bit about peptides, but everyone has their own opinion in their favorite peptides. So let's let's talk about peptides. Again, tell me what they are. And then we'll get into kind of your favorite peptides and their uses. Sure.
Dr. Neil Paulvin 3:40
peptides are small, most of them are small amino acids that are put together, they can be anywhere from like nine amino acids, some are in a couple hundreds, they are different, a lot of other things out there. So you can work on very special, they're very, a very special occasion there's special specific hormone area, or specific receptor, or they can work on acting a specific pathway like DNA D pathway, or they use to activate certain chemicals in the brain to help with either anxiety or depression or memory. So that's why they've kind of grabbed this niche because a lot of them have very minimal side effects. And they work pretty quickly when they don't really interact a lot of their medications which is why I really liked them as well that a lot of times if I were doing traditional medicine they would you'd have to give somebody a side effect a medicine for the side effect of the medicine they were already on like I'd mentioned like things like five myalgia so they could be anything from I mean it's exploding the last even three months it's like every week is a new thing going on but I've had everything done now everything from cream form to no spray to injection to now we're doing my v. so it runs the gamut.
Dr. Stephanie Gray 4:45
Wow. Wonderful. I spoke on Ari Witten summit about hormones and I believe you spoke on peptides and I haven't heard that talk. So I need to go back and watch that. That was the superhuman energy summit, which is wonderful for anyone listening, I would encourage you to check that out. So let's breakdown peptides into some of those categories and uses that you mentioned. So maybe starting with anxiety and depression, what peptides Do you use for those symptoms?
Dr. Neil Paulvin 5:09
The ones that are really out there now are I use a lot of C Max and C language or both either nose sprays or injectable, they work very well. The our VPC. 157, does have some activation on serotonin and dopamine. So it's used a nice add on, I think Yeah, like BBC is definitely my favorite pepex it's got so many it's got so many different uses, and really has no side effects. And then I'll combine it with something called d h HB which is not a true peptide but it's kind of become an adopted brother or cousin for in terms of anxiety depression does any brain issues I'll combine that with something called the the cerebral licen or di hexa. And then we always go he's got to fix the guy so again that BPC one few sevens we know there's definitely causation between the gut health and the gut, brain axis and, and so on.
Dr. Stephanie Gray 5:55
But let's talk about BPC 157 for a moment. So I first heard about that years ago, you know, getting injected into athletes who were having injuries and it could expedite the healing process. At least to my knowledge that's no longer available in that form. But we do carry it at our clinic in an oral capsule version that patients can take for gut health. Is that the what you're using?
Dr. Neil Paulvin 6:15
I mean, I do know we have I inject joints I okay. Patients injected all the time. Okay, I'm now starting to do it a lot IV. Wow. I had a patient come in, I do fog and fibro patients as well as something called quinolone. toxicity. They call it foxing. Now, yeah, it's become a it's become a really incredible treatment. I mean, there's patients who, six months ago couldn't walk and now they've gotten IV BBC combined with something called thymosin. Beta for some people may notice TV 500. Yeah. And it's gotten incredible results.
Dr. Stephanie Gray 6:48
So you're working with a different pharmacy than me. So yours, you're getting it?
Dr. Neil Paulvin 6:53
We can talk offline. I can definitely Absolutely.
Dr. Stephanie Gray 6:57
So the oral version that is available I have started using with my patients and I've been taking it myself, because its claim to fame is that it can help conditions like Crohn's and colitis and leaky gut syndrome, per se. So is that one application for the oral use that you use in your practice?
Dr. Neil Paulvin 7:12
I use the oral I mean, I'm now using high dose oral I use kind of three times four times the old school dose at this point. I also now founded the company that makes the BPC suppository and with the with UC also have kaleidos having some bleeding as you did this positivity for a month and a half and the bleeding has gone.
Dr. Stephanie Gray 7:34
Wow, that makes sense. Yeah. But it right where the problem lies. That's great. Yeah. And if the BPC 147 is helping heal the gut, then like you said, we have to start with the gut from a mental health perspective, heal the gut, and then the anxiety and depression will improve. Let's go back to those nasal sprays you mentioned. So are those providing a short acting effect? Or are the effects longer term is that something that has to be used multiple times a
Dr. Neil Paulvin 7:56
day? Definitely just once a day, what I tend to do is in a perfect world is I'll use I'll use kind of a stacking dose with the patient will do the C max three or four times a week and the C length the other three times a week. Okay? We're even given the day off in the middle just to see how it works with the brain gets accommodated to it. I tend to do it I'm the people who do it in perpetuity I usually will give him a month off in between after several months of using it. Sure. Because if it's working, it's working. If it's not, it's not anyway, then I'll use it like you said we combine it with other good stuff and propaganda pumps with up to very toxic things like probiotics and regulating their hormones and cortisol and things like that. So, but it's once a day to max for me at least.
Dr. Stephanie Gray 8:40
Sure. And are those peptides that can be used with medications of patients with anxiety and depression are medicated. You alluded to peptides not having a lot of interactions in the past can patients take the peptides also with medications they're already being prescribed?
Dr. Neil Paulvin 8:53
They can I tend to low dose than then I tell a person I got to make sure their doctor I don't prescribe a lot of those type of medications for my patients. They're coming in. They do that to another doctor. But also the doctors on board. I did tempted about half the dose they would be on normally. Okay. Yeah, they feel and go from there. Sure. So I do they can be combined. You just got to make I'd rather them go too low and then go really slow. Because we started tournaments. One thing you don't want to heist too much our turn that can get them in trouble. So that's the one that I'm a little cautious about.
Dr. Stephanie Gray 9:28
I get asked all the time. What's one product that I just can't live without when it comes to maintaining my own health and longevity? And my answer is something you've actually heard me mentioned on several episodes. It's called mitochondrial complex and it's pretty much the Cadillac of multivitamins, and it's packed with antioxidants, including three key players acetyl, l carnitine, alpha lipoic acid and N acetylcysteine. Think of a steam engine that requires coal to be continually shoveled into the furnace to power the train forward. acetyl l carnitine. Does that for your body by shuffling short chain fatty acids into your cells to provide Your body with energy. This is an absolutely essential task to keeping you running. However, what's a byproduct of fire? You guessed it smoke. Unfortunately, in this analogy, smoke from fire equals free radicals. To combat those free radicals. Other antioxidants are needed and that's where alpha lipoic acid and acetylcysteine come in.
Together, they scavenge free radicals and help boost and recharge gluta phi on the most potent antioxidant in the body. To top it off mitochondrial complex also contains a little bit of green tea extract, broccoli seed extract with sulforaphane and even resveratrol. Research has shown that when athletes and individuals that are under stress begin taking this product they are less likely to get sick as they're giving their body what it needs to conquer those stressors. Who doesn't need protection from stress and cellular damage at this time? I certainly do. I take this product every day. If you're interested in learning more about how mitochondrial complex can help support you living a longer healthier life, check out my blog post on why antioxidants are important found at your longevity blueprint comm forward slash why dash antioxidants dash r dash important for in chapter four of my book, Your longevity blueprint to get 10% off our mitochondrial complex just use code energy when checking out at your longevity blueprint.com. Now let's get back to the show. You alluded to thymosin beta and I want a lot of time, it's an alpha one also, or thymosin beta four, I think that was an alpha one, peptides can be used for immune modulation. And I've only just began really using these in some of my chronic disease patients. So let's talk about those two and break them down in their main applications
Dr. Neil Paulvin 11:34
to before thymosin beta four. Again, people may also if you're an athletic field may heard of it as Tb 500, which is a smaller fragment of it is that is in beta four is good for regular than uses and also boosts stem cell production. But also can increase blood flow to the area, which is why it does boost stem cell production. So it is good for boosting immunity has been used now with a patient with hepatitis and some other gastrointestinal issues, right. So that instead also people were technically off label using it as a COVID COVID coctail peptides. One is all important. Everything started in March. It's also great for recovery. It's great. I've used it in athletes for rotator cuff tears and things like that. But in terms of immunity, it's it's a nice it's has definitely has some utility, as I mentioned, that's the one peptide, which I will right now use about three or four months, and then I haven't take a break just because we don't know because of the of the stem cell production, I tend to give them a break. Some doctors disagree that the peptide was good, great about peptides is there's always a new one, there's, there's no, this isn't like a z pack or something where it's pretty textbook user packing see in three months. So it's always a learning curve.
But that's the one thing in terms of diamond snap. For one. It's like the holy grail right now, in terms of first with immunity, just had some really good studies come out with COVID that it did help in terms of immune reaction to it. So it has been shown to get help hepatitis, it's been shown to use your natural killer cells regulate your th one versus th t ratio, th 17. So it does all the great things that you want any natural treatment to do to resume uni. But also some hard studies behind it to back it up. But also has some huge anti aging protocols, part of which is just higher dose, but also being done IV now, which is great for quicker higher boosts. I mean, it's been used kind of out, again, off label with COVID patients IV. I think they're doing some further studies on that now. So it has a great immune boost. And I think it should be that along with PVC shouldn't be in the water supply at this point. I mean, tier one is greatest has also been already approved by the FDA. So people still get worried about things that aren't FDA approved, quote unquote. So that gives you a little bit more leeway there too.
Dr. Stephanie Gray 13:47
Sure, yeah. A previous medical doctor I interviewed on this podcast who got COVID uses peptides heavily and he said thymosin Alpha one was certainly part of his protocol to get better, but something that could be taken as more of a preventative to boost your immunity so you don't get sick or if you get sick, you can take more of it to help you recover. And just to explain to the audience, which I'm sure you can expand better on this, because I have this minimal understanding of peptides but as we age, I see a menopausal population. I like to tell my patients that the ovaries kind of shrivel up and throw in the towel right, the ovaries don't really help so much as we age many times when they're done, they're done and the same is true with the thymus gland. So the thymus gland also can essentially shrivel up or atrophy so it's not helping with immunity like it should be and that's where these famous in you know, peptides come in. So hence the name famous an alpha liner thymosin beta one, they're helping with T cell production that's supposed to be coming from the thymus gland. Do you want to expand on that at all?
Dr. Neil Paulvin 14:42
It's definitely been shown to boost both antibody Muni and cell based immunity, which is both fighting a bacterial infection and then long term producing antibodies, which again why it becomes it's great for everything including COVID boosts natural killer cells will help get your body to break down for By the way, help kind of eat up infection, I can't have a better analogy for it. So it does all those things. So again, I said it kind of gives the show of the thymus somehow.
Dr. Stephanie Gray 15:11
Yes, yes. Yeah, exactly. So lots of applications, there can be extremely helpful. And like you said, you had be better to be in the water supply, that fluoride and some of the other things they're putting in, in our water supply. But what about weight loss? So patients usually as they age, body composition tends to change. So many patients want to lose weight, get that extra edge. So what peptides Do you use there, I
Dr. Neil Paulvin 15:32
have to ask. Weight loss is because obviously, always is one of those hot button topics. There's a bunch. So let's see if it depends on what the patients are looking for. So first of all, there's something called Alexa Knox, which helps boost insulin sensitivity, get rid of insulin resistance, works in the IQ three pathway, a lot of alphabet soup there, which helps with weight loss, it's three times a day to pill, which people like as some people are not fans of injecting themselves socially like that, you can combine that with what's called tcaa cream, which is quote unquote, fat loss cream. Yeah, that's great for those people, for the love handles or something that local area. But it's not obviously going to you can't put on your whole body or bathe in it, but some people would love to at some point. But so I mean, that's the starting point is a new one out called mazzi, which you may have talked about in some of your mitochondria stuff. But also because it does improve insulin resistance and helps with weight loss. It also helps these get a boost na D gives you a better workout to lose more calories and so on so forth.
There's also then the other big grouping is the growth hormone peptides, right, though it's on my pages, it really depends what your goals are. I have athletes who want more springtime, they want to get leading cut and look good on the beach, the big gun there some called test Marlin. Unfortunately, it's insanely expensive. Right now it's $700 a month, then the kind of below that is what's called cjC and EPA merlon, which is pretty good. It's not as strong as test run. And then there's a smaller fragment something called a od, which is good for joint pain. And for weight loss. It's that's kind of become its niche. And that works very well. So it's usually a combination by really depends on how aggressive patients want to be. And what's good as you can go from injection to cream to pill to every patient has their own. What they want
Dr. Stephanie Gray 17:23
preference. Yeah, totally. Yeah, that fat loss cream immediately as a as a female. When I heard about that initially, I thought, Oh, I want to try that. And I haven't yet but that's something that can be used around the knees, right? If you're having kind of some saggy tissue there. I mean, it can be used in areas that you whatever areas you you would like to use it on. You alluded to nada. So let's let's transition a little bit to talking about mitochondrial dysfunction. Why does it negatively impact longevity? And then we'll kind of talk about some things like an ad that can help. So what's mitochondrial dysfunction?
Dr. Neil Paulvin 17:53
How long do we have at this point? But yeah, mitochondrial dysfunction is pretty much I mean, mitochondria does a lot of different things. Obviously, it's the battery part of your, your battery, it's your energy's all your ATP or energy has produced a lot of your proteins, it helps regulate your DNA. So all those different things are done in the mitochondria. So if one is dysfunctional, obviously, it's not doing something right. infection, inflammation, oxidative stress, which is when you know, the reactive oxygen species or reactive nitrogen species caused damage, then it kind of just like somebody, you kind of have your big Lego set, and you kind of start breaking pieces of that Lego thing down and it's not connected anymore. So when it's not connected, things don't work as well. So first, people will get a lot of fatigue, if the energy part is not working. We're now noting that the other part of the mitochondria called the endoplasmic reticulum, which has made your proteins that now is now being in the last year is now something called endoplasmic reticulum stress. When we're fine, there's a huge association between that and calcium buildup in the mitochondria makes it not work as well. So they're actually using calcium channel blockers or the blood pressure medicine to block that. And we're also finding a huge association between that and like neurodegenerative diseases such as like Alzheimer's or Parkinson's. So that's an issue and another thing you can see I mean, you could get fatigue you get brain fog or memory issues. Also DNA toxicity, things you mentioned na D if they do not produce na deactivate certain proteins, like what's called carbs and some other things like p 53. That can help get rid of the some of the DNA damage and kind of recycle it if that doesn't work. You're in trouble. So that's, that's the short version of what can happen. That means also associated to that and diabetes. So the key is right now we're finding more and more that every time you talk about cholesterol and everything else take care of your body, you need to take care of mitochondria that takes care of you. So yeah,
Dr. Stephanie Gray 19:45
so true. So on past episodes, and we kind of talked about this before starting the recording today I have talked to other guests who have mentioned their favorite mitochondrial boosting nutrients things like carnitine and alpha lipoic acid and N acetylcysteine na seems to be a new popular buzzword and ad something in the last couple years. I know I always hear about it anti aging conferences, whatnot. So it sounds like that's something that you also utilize. It sounds like you do a lot of IVs. In your practice, do you offer an IV sublingual, what's your patch form, what's your favorite way to administer that?
Dr. Neil Paulvin 20:18
It depends on the patient, if they're looking for the most bang for the buck is still IV. But if you're going to do IV, now we're finding that you definitely want you need to do a stack of pi four times within two weeks, at least to do it, I go really fast. And I can get in my patients in about two hours, some doctors do it over four or five hours. So I tell my patients, if you can't either a don't have time to do it for four or five times, or unfortunately, it's expensive to do. If you don't, then don't start you can't dip your toe into the IV if you're going to do it, do it. Otherwise, a lot of other forms like you mentioned, my favorite besides that is probably the patch at this point. The one caveat, I've had a couple people get allergic to the adhesive sure and feel worse, but probably my second favorite be the patch. Otherwise, now there's there's new na de melts, melt tabs, our patients are really loving. And I also recommend all my nav patients to do either in any D booster and PA NPK booster which has produced an ad. If you're going to again, if you're going to do it, just do it and get the backside benefit of it.
Dr. Stephanie Gray 21:20
Sure. So I had asked my one of my first guests who talked about NHD. about, Well, a couple things here about the na di vs. And she was explaining that some of our patients get that kind of stomach flipping sensation. When you are administering them that fast does that go away with time with consecutive IVs? Or do they get that sensation with each IV,
Dr. Neil Paulvin 21:41
most patients will get written out to happen as much. And also when we do it that fast we want to then we can give them a script like giving like a zofran to the anti nausea medication, we just find that it works patients get a much bigger bang for their buck. When they go it goes a little faster. If they can't tolerate this, we can slow play it and do the four hour. But most honestly, most patients who are coming to see me for IBS, they're asking for like four days become a competition. If you wait online, have you ever looked at some of the groups or didn't two hours? No, I did an hour and 32 minutes, it's kind of like it's gone. It was the opposite. But it can cause that in their scope patients would just be really got to go really, really slow.
Dr. Stephanie Gray 22:20
Sure. So my second concern with that, because through my training with like Dr. Ben Lynch and hearing about how you treat over methylation, or you can use it an ad for that you can use or just like nice in general, but to treat over methylation. My concern was that okay, all these patients are getting pumped full of an ad, is that actually hindering or blocking methylation? And I asked one of my past guests and she said, I don't know, that's a good question. Well, since that time, months have passed, I have asked many people and they said actually, that is that is legitimate. That is a concern. We do want to make sure that we aren't essentially impacting methylation negatively by overuse of na D. So what are your thoughts on that?
Dr. Neil Paulvin 22:56
Exactly? You said, I mean, there's initially it was kind of like, yeah, and now it's really it's become an issue. I mean, we do regulate it. I mean, we also check if we do tell patients that they have certain overcometh over methylation symptoms, let us know, I haven't had anybody with the issue yet. I haven't and I know the one or two boys have had the issue. It's a theoretical possibility. I just haven't hang out with it. I always do let the pages know when I if somebody doesn't like an mthfr, or one of the other mutations, I make sure they're aware of what the possibilities are.
Dr. Stephanie Gray 23:28
And then we could I suppose I don't give any di V's but I suppose you could give methylation support as well then to prevent the impact on methylation by the NHD.
Dr. Neil Paulvin 23:37
You can Yeah, you can most of my patients are already on a B, some type of methylation protocol if they need it. We don't want to give anything the day of the IV usually, because otherwise it doesn't work as well. But you can definitely get them if they have an issue, you can definitely give them support on the back end. Sure.
Dr. Stephanie Gray 23:52
Sure. Well, let's talk a little bit about NRF two modulators. First, what is NRF? Two? Why do we need to know about that?
Dr. Neil Paulvin 24:00
anybody's probably listened to your podcast knows by Bluetooth ion how it's a great antioxidant pine about nacra and a C? Yep. nerf two is kind of the Forgotten antioxidant cousin may actually be better than the rest of them at this point. From my perspective, I mean that their studies coming out in terms of how it works, it does have a kind of a brotherhood with NPD in terms of the way it's activated. Of course now I'm forgetting the abbreviation of its key. It's the key path when there's another pathway, which, of course, I'm blanking on, but it's a very strong antioxidant. They're also finding now that it has anti cancer possibilities, as well as ability like an ad does to help protect any type of DNA from DNA damage, but it can be taken in some form. There's a couple different companies that make them now they're a little bit different combinations, some of green tea, some have resveratrol, some have self I can't pronounce his
Dr. Stephanie Gray 24:50
Dr. Neil Paulvin 24:53
I never can say it right. And there's different combinations. I know there's a bunch of stuff coming down. The pike was supposed to come down the pike before the pandemic. I pretty much tell all my patients who are in as part of their initial mitochondrial cocktail cocktail exactly, that I add that in there with some of the other things that you probably talked about in the past and, and they tend to feel a little better. I mean, it's one of the ones where they'll some things you just don't know that they're getting better than just the lab work shows or whatever this they actually feel a little bit more energy within a couple of weeks years.
Dr. Stephanie Gray 25:25
I know another antioxidant that you use that we have not yet talked about on the podcast is pq, q,
Dr. Neil Paulvin 25:31
p p q, I really liked I didn't realize how good it was. And now there's a bunch of studies coming down the pike, pike they've already been released, that when combined with some of the peptides have really helped with oxidative stress and kill oxidative stress and has the mitochondrial biogenesis, which is the dividing division that the reproduction of the mitochondria, it also has potentially fixed the mitochondria energy, what helps produce ATP is called a mitochondrial transport chain. Again, it's like a little connection of slides as we I tried to explain it the patient so if it's their own auto connected, things don't work well, it actually may heal that it also may help with oxidative stress, which is again, the damage from free radicals. Or they're kind of like the breakdown products that cause the breakdown bad guys a breakdown bullies that you can have in your within yourself themselves. It's definitely part of my cocktail with another product. It's called lambda Q, which also helps mitochondrial damage. And it's kind of become my go to I mean, literally the last two months I've seen, I think three or four studies that show how efficacious pq q was, it was kind of used to be below the ones you mentioned previously. And now it's kind of jumped this stuff up the list a little bit.
Dr. Stephanie Gray 26:40
And pq q sometimes for the listeners, you can find in other products, like we have a B complex, it's from pure encapsulations actually, that has you know all the methylated B vitamins plus pq q in it, sometimes you'll find that in combination with other products. And then Mitel q for the listeners is coenzyme Q 10. So it's a specific form supposedly better absorbed version of CO q 10 there so they know what that Mito Q is. So I know you work with a lot of athletes. So I know you help improve mobility. So why does mobility matter? Why How does mobility help our health and longevity,
Dr. Neil Paulvin 27:14
mobility helps because we're finding more now that it's great that you work out and build muscle muscle mass is obviously very important. But if you become stiff, then one is the joints themselves will become inflamed, and lack of range of motion leads to inflammation that leads to breakdown of the muscle which leads to potential nerve damage, which can also can lead to weight gain, the more immobile you are, as you get older lead to things like osteoporosis or just a joint pain in general. Also mobility will start localized, it could be your shoulder could be your low back from sitting on doing all your zoom calls for the last six months, whatever it is, and then it's going to spread to your mid back and then it's going to spread to your shoulders because that's one thing locks up the other thing gets eventually it has to overwork and then it gets locked up and so on. That affects certain things, it's gonna The main thing who knows now that it can affect breathing and your diaphragm we know now will trigger most people who listen to your podcast or, or did diaphragmatic breathing, or meditation or calming or yoga or any of those types of things. And that diaphragm is not moving and you're not able to get the exhale the toxins and also more effective than effective Vegas nerve and which leads to all other side effects. So mobility is not just about oh my shoulder, I have a little bit of shoulder pain, it could actually be things like, again, your pecs, your diaphragm, it could affect the nervous system then will affect the lymphatic drainage system, which will affect your buys ability to detox. So it's a snow. It's a snowball effect. I mean, I never doing mobility work 10 years ago, and now I do it every day. I mean, it's become a thing now, I mean, I mean, if you're on social media, everybody's a mobility workout now. And it's, it's beneficial to the athletic performance also beneficial in terms your health because it affects ganyan lymphatics, it affects your ability to detox.
Dr. Stephanie Gray 29:01
So tell me about these mobility workouts, how do we improve mobility,
Dr. Neil Paulvin 29:05
improved mobility, you can do one of two ways. I recommend that it depends on what your lifestyle is. And I definitely recommend you private alternate between doing joint specific and the one I love. The program is called kin stretch k n stretch, because it's actually it's like stretching for your joints. So they have very specific mobility drills feel your shoulders and your hips. I would recommend doing that once or twice a week with either a foam roller, massage ball, whatever you use, and then doing a full body mobility to live mobilize your fascia, cat cow we call the scorpion stretch pigeon, things like that. They're much more generalized things. I haven't had pages now that foam roll or do massage ball on their abdomen to mobilize to detox or even have patients who mobilizer chest muscles that they're on the younger side to help again help the better that your respiratory muscles are breathing and also stimulate your vagus nerve. Just keep working So you want to mix and match that stuff?
Dr. Stephanie Gray 30:02
Sure. It sounds like going to yoga can be very helpful for also just in general.
Dr. Neil Paulvin 30:06
Yoga is awesome.
Dr. Stephanie Gray 30:08
What about inflammation? So how does inflammation affect our health and longevity?
Dr. Neil Paulvin 30:16
How much time do you exactly? Yeah. I mean, inflammation affects everything at this point is huge. Now in brain health. I mean, that's again, back to PVC. We find that patients who have no brainers we get the inflammation down. Because of some type of blood brain barrier issue. It's incredible. We know it affects weight gain. We know that affects just energy levels, in general, it's gonna affect the mitochondria to be from the food you eat. If you eat inflammatory foods, you're eating sugar and gluten every day. So it affects every part of your health. It could be from what you're getting what you're eating, not exercising stress, obviously can lose your inflammatory levels. So that's why you want to do some combination again of mind body exercise, supplementation peptides and kind of have that program. I mean, besides the mitochondria, controlling inflammation is one of the biggest things that you can do and eating right. In terms of affecting your health.
Dr. Stephanie Gray 31:10
What are your top supplement recommendations for reducing inflammation?
Dr. Neil Paulvin 31:15
I love PPC, obviously I do. high dose PPC. I love CBD high dose. Sure. I love curcumin. Yep. Which is an old school good one I really like is called resolvins, which is a specific Fishel derivative. I haven't used it as much lately, but I know it's definitely it's made by a couple different companies. It was from MIT. I'm not sure who exactly i think was from MIT. And it's incredible. I mean, if you do it the right way, it does take a little longer takes about two or three months to really get the full benefit of it. But it has incredible results from everything from joint pain to like five myalgia patients, by the time I go twos.
Dr. Stephanie Gray 31:52
So speaking of fibromyalgia, let's go back to pain. So I know you offer natural options for pain relief to your clients. And maybe you've already spewed all those out through your past questions. But when we think of pain in general, I know I'm just asking you to cut to the chase in and give her our listeners some some tips. But what do you recommend for pain relief
Dr. Neil Paulvin 32:10
payments, kind of the ones that part of what I just mentioned, if those core for automation really well, I think and more on again, mine by doing a 25 minute breathwork session really works well. Something I really like to have been brought up is red light therapy, if you can either get access to a red light bed, which is my go to I mean, I'm in Manhattan. So there whenever two blocks, and other places in the country, that patient I say another night is readily available. I tell patients that they find that that does help them to definitely get one at home, don't get the bed the bed about $1,000 we shouldn't get these portable units, which are about a couple $100 I work incredibly well also fixing mitochondria. Other things I'd like for pain is really more than doing a deeper dive and seeing what else is going on. I'm talking
Dr. Stephanie Gray 32:54
right i mean even optimizing testosterone can help with pain because it helps a blood flow. So you know even optimizing hormones is a is a piece of that puzzle.
Dr. Neil Paulvin 33:02
And God I've been I've been I always will, if they have got ain't always checking for like things like mean CBOE or Lyme disease. But I also do a decent amount of if your pain is not going away with two or three different types of treatments, it's probably something else going on checking gut check for some type of infection. And that jusy is something that's kind of or mold. And that's kind of the door jamb preventing you from getting better.
Dr. Stephanie Gray 33:24
Sure. Sure. Well, I have to ask about nootropics. Because that that's also one of those more popular buzzwords, and you know, providers who are staying progressive have to know how to respond to that question when patients come in and they want nootropics. So what are your recommendations there?
Dr. Neil Paulvin 33:40
There's so many now. So I'll touch to it break down really quickly into different buckets. First thing you need to figure out if you want to do is it like an add type person? Or are you just looking to take your brain to 11 this because it's different things for different issues. But I definitely am the simple things to take are things like Lion's Mane is great, it's very easy to get and not insanely expensive. I really like doing something called RG three, which is a combination of ginseng, on which racecar drivers use or pressure on dogs of use for really good focus and also decreased inflammation in the brain. So I really that's one of my go twos. It's pretty have really minimal side effects to it.
Dr. Stephanie Gray 34:17
And that's a compounded product, right? Because I think of that as being stimulating is that going to cause anxiety or palpitations, like caffeine would
Dr. Neil Paulvin 34:26
if somebody has either one of the genetic mutations. I've had one person who is very sensitive to it. I've never had anybody else be sensitive to it's possible. Okay, I haven't had any of those. I stopped people at a lower dose and then I progressed them up as needed. So in terms of, I mean, those are the basic ones. I mean, other things that are really good as I'm called alpha GPC. That could be mixed with Lion's Mane husband with your co lead levels. And then you getting the other trap ties we talked about seamax and sealink help, a little help. And then the big gun is what's called cerebral license which if Again, if it could be in the water for anybody from memory issues to unfortunate occasion for any type of traumatic brain injury, incredible nootropic.
Dr. Stephanie Gray 35:07
I don't use that one. Is that an injection? Or how's that administered?
Dr. Neil Paulvin 35:10
It's an IM injection. So most PE some who are a little hesitant to do it also, now it's IV. So it's a bigger gun. It's not something that you can just get. That's not when you're dipping your toe. I mean, there's other ones. I mean, bukoba. There's tons of other ones out there. A lot of people love massages, ketones is another one. Sure, either people who go on a keto diet will feel that they get a much more cognitive improvement. Unfortunately, patients have Alzheimer's or some type of neurodegenerative disease. They're going they're putting them on keto diet, and they thought that their memory does improve. So that's one that you can do either do a keto diet or do some form of Dinah's ketone with MCT. Oil. ca specific, some people like missing thenI with DNA and people really like clustal serine, which helps with adrenal accessor breakdown is really good, too.
Dr. Stephanie Gray 35:56
Yep. Okay. Wonderful. You flooded us with lots of information in a short period of time. And some of this may be a little over the head, some of my audience, but I at least they can, you know, take notes and go back and listen again, if there's one of these peptides, they want to try whatnot. So thank you so much. I know you're in Manhattan, but it sounds like your main website is Dr. Paul Van p au, l vi n calm, and you do have a free gift on your website for listeners. So tell us what that is.
Dr. Neil Paulvin 36:21
Yeah, we talked about definitely have been important to mitochondria. So you definitely can download the free energy guy to kind of break down a lot of the things that we talked about for the mitochondria in the tropics. And it's a nice little easy Starter Guide of the alphabet soup that we went through today.
Dr. Stephanie Gray 36:36
Exactly the alphabet soup. Well, thank you Dr. Pavin for coming on the show today talking about the new tropics and inflammation and mobility and peptides and hormones, everything that I think most of us need, and we should want to learn more about. So thank you so much for providing that complex information in a more understandable fashion. So it was an honor to have you on the show. Thanks for coming on.
Dr. Neil Paulvin 36:55
Thanks. It was fun. Thanks for having me.
Dr. Stephanie Gray 37:00
Wow, smart guy. They're clearly well trained in lots of peptide therapies. If you're interested in exploring the use of peptides, yourself, schedule a concert with Dr. Paul or myself to talk through the best options for you. Be sure to check out my book your longevity blueprint. And if you aren't much of a reader, you're in luck, you can now take my course online where I walk you through each chapter in the book. Plus for a limited time, the course is 50% off, check this offer out at your longevity blueprint.com and click the course tab. One of the biggest things you can do to support the show and help us reach more listeners is to subscribe to the show. And leave us a rating and review on Apple podcasts or wherever you listen. I read all the reviews and would truly love to hear your suggestions for show topics, guests or how you're applying what you've learned on the show to create your own longevity blueprint. A podcast is produced by the team at counterweight creative. As always, thanks so much for listening and remember, wellness is waiting.
The information provided in this podcast is educational. No information provided should be considered to be or used as a substitute for medical advice, diagnosis or treatment. Always consult with your personal medical authority.
Transcribed by https://otter.ai
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